I Feel Washed Out

I really hope I get the call from Dr. K.’s office soon about the Ocrevus switch. Like really, really soon. I’ve felt the Tysabri withdraw for far too long. I’m sick of it and I’m passed it. And I want to get on Ocrevus ASAP. I am still not sure about ocrevus. It’s probably the same way I felt about Tysabri when I was switching to it, yet I fear the results weren’t as optimal. Of course, what I really hope is that it’ll be a steady disease stopping drug, unlike Tysabri where you’d feel really good after the infusion, but I’d be jonesin’ for it the last two weeks (8 week schedule). Did I feel that when it was every 4 weeks? No! But do I want PML? HELL NO! C’mon Ocrevus.

Somewhat Reassuring

I’ve been kind of regretting the decision to switch off Tysabri. I mean, yes, I did have a slightly noticeable Attack/Episode/Relapse* that was confirmed by a MR (it’s the main image on this site) that means the 8 week dosing of Tysabri was allowing too much immune cells through the blood brain barrier. And the great Dr. K has been trying to get me off Tysabri for a while. When the pills started coming out, Dr. K tried to get me to switch. I considered it, but I decided to stick with the highly effective Tysabri. And glad I am, as the pills (eg tecfidera) just doesn’t show the same efficacy as Tysabri.

So I’m obviously nervous about switching. I hope Ocrevus works as well or better than the Tysabri. And here is s an article that says, “Ocrevus outshines all other DMTs.”

Wow, that’s awesome! However, I have yet to confirm that Ocrevus is more effective than Tysabri. Sure, it may be safer*, but is it as effective. The great Dr. K. said it SEEMS to be as effective or nearly effective as Tysabri, but with less ups and downs. That’s good. I mean I do enjoy the Tysabri boost that comes a couple days after infusion, but it comes with an equal low on the 8 week dosing schedule. That also is a huge reason I decided to switch.

So yeah, as I’ve mentioned before, I’ve made the decision to switch. Now it’s just a matter of making it to my Ocrevus infusion in a couple of weeks. Hopefully after 07 February.

*As no cases of PML have been found on Tysabri users that first washed out for three months before beginning Ocrevus. However there have been some PML cases in those that switched from Tysabri to Ocrevus immediately. I’m happy to make sure I don’t get PML, even if it does mean an extra month of the suck. As I always say, I sure as hell don’t want to become a PML case.

New Year, New Regimen

My Tysabri Infusion was supposed to be today. But I’m getting off the stuff. Because of the PML risk. It works….really well. At least on the four weeks schedule. The eight weeks seems to be allowing the immune system to pass through a bit. To prevent the risk of erasure by PML. But that also let my killer immune system thought and it caused a minor attack. Bummer, which is why I’m switching. Basically, what I’m taking from it is Ocrevus won’t give me the highs and lows that Tysabri brings, but instead will be a much more level treatment that won’t leave the last two weeks saying, “Oh man, I need my Tysabri!” I should be getting on Ocrevus in early February. And it better work. As well as Tysabri. As I won’t be going back…at least that’s what I took from the great Dr. K.

And I’m officially one month (four weeks) from being washed out today.